Table 2.

Selected Parameters in Slu7 Knockdown Mice after Ethanol Feeding

Parameters	Ad-shRNA	Ad-shRNA + ethanol	Ad-shSlu7	Ad-shSlu7 + ethanol
Starting body, g	20.16 ± 0.4	20.53 ± 0.3	19.96 ± 0.4	20.54 ± 0.2
Final body, g	23.32 ± 0.3	21.61 ± 0.5	22.92 ± 0.4	21.77 ± 0.35
Liver, g	1.02 ± 0.02	1.00 ± 0.03	0.93 ± 0.02	0.95 ± 0.03
Liver/body, %	4.3 ± 0.05	4.6 ± 0.09∗	4.0 ± 0.05	4.4 ± 0.09∗
Liver cholesterol, mg/mg protein	1.04 ± 0.04	0.98 ± 0.2	1.02 ± 0.03	0.99 ± 0.1
Serum
Triglycerides, mg/dL	40.68 ± 1.62	67.73 ± 2.68∗	34.61 ± 2.17	63.05 ± 2.55∗
Cholesterol, mg/dL	87.52 ± 7.7	111.63 ± 4.0∗	99.37 ± 6.5	115.54 ± 4.0∗
β-Hydroxybutyrate, mmol/L	0.20 ± 0.02	1.74 ± 0.3∗	0.20 ± 0.01	0.9 ± 0.1∗†

Female C57BL/6J mice, aged 10 to 12 weeks, were divided into four groups, as follows: pair-fed Ad-shRNA control; ethanol-fed Ad-shRNA; pair-fed Ad-shSlu7 control; and ethanol-fed Ad-shSlu7. Data are expressed as means ± SEM. n = 5 to 12 animals.

^∗P < 0.05 versus pair-fed Ad-shRNA controls.

^†P < 0.05 versus ethanol-fed Ad-shRNA.