Table 3.
Selected Parameters in Slu7 Overexpression Mice after Ethanol Feeding
| Parameters | Ad-GFP | Ad-GFP + ethanol | Ad-Slu7 | Ad-Slu7 + ethanol |
|---|---|---|---|---|
| Starting body, g | 20.13 ± 0.3 | 20.73 ± 0.3 | 20.46 ± 0.3 | 20.20 ± 0.3 |
| Final body, g | 22.4 ± 0.2 | 20.93 ± 0.46 | 22.11 ± 0.7 | 20.46 ± 0.5 |
| Liver, g | 0.93 ± 0.06 | 1.04 ± 0.01 | 0.97 ± 0.03 | 0.99 ± 0.02 |
| Liver/body, % | 4.0 ± 0.003 | 5.1 ± 0.001∗ | 4.0 ± 0.001 | 5.0 ± 0.001∗ |
| Liver cholesterol, mg/mg protein | 1.16 ± 0.09 | 1.33 ± 0.04 | 1.36 ± 0.08 | 1.27 ± 0.05 |
| Serum | ||||
| Triglycerides, mg/dL | 43.43 ± 3.21 | 78.19 ± 3.66∗ | 35.42 ± 2.49 | 79.41 ± 4.04∗ |
| Cholesterol, mg/dL | 73.2 ± 10.95 | 130.96 ± 6.41∗ | 98.4 ± 6.01 | 94.41 ± 8.11 |
| β-Hydroxybutyrate, mmol/L | 0.25 ± 0.03 | 1.26 ± 0.1∗ | 0.24 ± 0.02 | 1.83 ± 0.1∗† |
Female C57BL/6J mice, aged 10 to 12 weeks, were divided into four groups, as follows: pair-fed Ad-GFP control; ethanol-fed Ad-GFP; pair-fed Ad-Slu7 control; and ethanol-fed Ad-Slu7. Data are expressed as means ± SEM. n = 5 to 12 animals.
∗
P < 0.05 versus pair-fed Ad-GFP controls.
†
P < 0.05 versus ethanol-fed Ad-GFP.