Figure 2.

MS spectrum of canagliflozin obtained under acidic (0.1% v/v TFA in water) and neutral pH (10 mM ammonium acetate in water, pH 7) (A). In acidic conditions, many in‐source fragments are formed (*), In the ammonium acetate buffer the ammonium adduct [M + NH₄]⁺ is the main ion. (B) Shows the MS spectrum of celecoxib under neutral conditions (10 mM ammonium acetate in water) next to the protonated molecule [M + H]+, a kalium adduct [M + K]⁺ and an in source dimer [2M + H]⁺ can be observed