Table 2.
Cox regression analyses on the influence of patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) G/G genotype on transplant‐free survival in A the overall cohort, B among patients with viral hepatitis and C among patients with alcoholic (ALD)/non‐alcoholic fatty liver disease (NAFLD) (cohort I)
| A | B | C | |||||||
|---|---|---|---|---|---|---|---|---|---|
| All patients, n = 372 | Viral hepatitis, n = 231 | ALD/NAFLD, n = 141 | |||||||
| Patient characteristics | HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value |
| Age, years | 1.03 | 1.01‐1.05 | 0.004 | 1.03 | 1‐1.06 | 0.041 | 1.04 | 1.01‐1.08 | 0.008 |
| Sex, male vs female | 0.689 | 0.415‐1.14 | 0.15 | 0.648 | 0.332‐1.263 | 0.202 | 0.619 | 0.255‐1.5 | 0.288 |
| Aetiology, viral vs ALD/NAFLD | 0.651 | 0.404‐1.05 | 0.079 | — | — | — | — | — | — |
| HVPG, per mm Hg | 1.01 | 0.976‐1.05 | 0.498 | 1.05 | 0.994‐1.11 | 0.079 | 0.975 | 0.925‐1.03 | 0.356 |
| MELD, per point | 0.986 | 0.933‐1.04 | 0.611 | 0.974 | 0.891‐1.06 | 0.558 | 0.989 | 0.92‐1.06 | 0.768 |
| Albumin, per g x L−1 | 0.917 | 0.885‐0.952 | <0.001 | 0.907 | 0.851‐0.966 | 0.002 | 0.923 | 0.881‐0.966 | 0.001 |
| PNPLA3 G/G | 1.42 | 0.879‐2.3 | 0.151 | 0.845 | 0.358‐1.99 | 0.7 | 2.16 | 1.15‐4.06 | 0.017 |
HR, hazard ratio; 95% CI, 95% confidence interval; HVPG, hepatic venous pressure gradient; MELD, model for end‐stage liver disease.