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. 2018 Aug;188(8):1895–1909. doi: 10.1016/j.ajpath.2018.05.006

Figure 6.

Figure 6

Differences in hepatoblastoma (HB) occurring in lipocalin 2 (Lcn2) knockout (KO) versus wild-type (WT) mice after Yes-associated protein-1 (YAP1)–β-catenin expression. A: Representative immunohistochemistry for proliferating cell nuclear antigen (PCNA), cyclin D1, and glutamine synthetase (CS) in WT and Lcn2 KO livers 6 to 7 weeks after HB induction. B: Representative immunohistochemistry for CD45 in WT and Lcn2 KO livers 6 to 7 weeks after HB induction showing modest increase in overall inflammation in Lcn2 KO mice. Blastemal areas in WT and Lcn2 KO HB shows an increase in CD45-positive cells in these areas, but numbers are more pronounced in Lcn2 KO mice. Original magnification, ×100 (A and B). CF, crowded fetal.