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. 2018 Aug;188(8):1895–1909. doi: 10.1016/j.ajpath.2018.05.006

Figure 7.

Figure 7

Differences in macrophage and neutrophil infiltration in hepatoblastoma (HB) occurring in lipocalin 2 (Lcn2) knockout (KO) versus wild-type (WT) mice after Yes-associated protein-1 (YAP1)–β-catenin expression. A: Representative immunohistochemistry for the macrophage marker F4/80 showing large numbers of macrophages infiltrating HB tumors in both Yap1–β-catenin–driven tumors in WT and Lcn2 KO livers. B: Representative immunohistochemistry for the neutrophil marker neutrophil elastase showing a few neutrophils infiltrating the Yap1–β-catenin–driven HB tumors in WT and Lcn2 KO livers. Original magnification: ×50 (A and B, top rows); ×100 (A and B, bottom rows).