Figure 1.

c-Cbl correlates with the survival of metastatic colorectal cancer (mCRC) in humans. A: Four representative images of CRC tumor explants from 72 patients with stage IV CRC stained with c-Cbl antibody. The c-Cbl expression varies from low (left panel) to high (right panel). B: c-Cbl expression was estimated using color-based image segmentation pipeline. Two stages, including RGB color image conversion to L*a*b space followed by segmentation of the color image into three subregions using a clustering algorithm, are shown. C: The c-Cbl expression was divided into high and low expression based on the median normalized c-Cbl expression. The survival of patients with CRC was examined using Kaplan-Meier analysis based on c-Cbl expression. The survival curve for both these groups is shown. The plus sign refers to censored records. Original magnification, ×20 (A and B).