Table 3.
Mean (SD) and Percentage Change From Baseline for AeUR, FEUA, and CLUR During Urine Collection Intervals After Multiple Daily Doses of Verinurad, Allopurinol, and the Combination
| 0‐ to 12‐Hour Interval | 12‐ to 24‐Hour Interval | 0‐ to 24‐Hour Interval | ||||
|---|---|---|---|---|---|---|
| Treatment | Mean (SD) | Change From Baseline (%) | Mean (SD) | Change From Baseline (%) | Mean (SD) | %Change From Baseline |
| AeUR, mg | ||||||
| Baseline | 418 (43) | 264 (68) | 683 (98) | |||
| VERU 10 mg | 490 (71) | 21.4 (23.3) | 250 (52) | 4.2 (48.0) | 739 (84) | 9.9 (21.5) |
| ALLO 300 mg | 231 (45) | −46.8 (7.3) | 180 (46) | −45.4 (14.5) | 363 (73) | −47.4 (7.6) |
| VERU 10 mg + ALLO 300 mg | 360 (73) | −11.4 (20.1) | 170 (48) | −27.8 (41.4) | 522 (105) | −21.6 (15.8) |
| FEUA, % | ||||||
| Baseline | 4.84 (0.56) | 3.58 (0.76) | 4.45 (0.54) | |||
| VERU 10 mg | 11.6 (3.77) | 160 (96.6) | 5.88 (1.78) | 49.9 (21.9) | 9.19 (3.28) | 77.4 (36.0) |
| ALLO 300 mg | 4.06 (0.47) | −9.7 (9.2) | 3.19 (0.62) | −7.6 (14.6) | 3.69 (0.59) | −12.0 (12.2) |
| VERU 10 mg + ALLO 300 mg | 11.0 (2.16) | 128 (67.6) | 5.17 (2.12) | 31.8 (26.0) | 7.93 (2.0) | 78.4 (48.9) |
| CLUR, mL/min | ||||||
| Baseline | 7.03 (0.44) | 4.18 (1.23) | 5.67 (0.92) | |||
| VERU 10 mg | 16.3 (4.57) | 153 (77.0) | 6.74 (0.96) | 95.5 (148) | 11.5 (2.74) | 122 (105) |
| ALLO 300 mg | 6.50 (1.18) | −6.0 (12.0) | 3.62 (1.30) | −9.4 (23.2) | 5.00 (1.13) | −8.50 (14.8) |
| VERU 10 mg + ALLO 300 mg | 17.9 (6.69) | 163 (99.0) | 6.41 (2.19) | 85.0 (164) | 11.8 (4.5) | 125 (103) |
AeUR, amount of uric acid recovered in urine; ALLO, allopurinol; CLUR, renal clearance of uric acid; FEUA, 24‐hour fractional excretion of uric acid; VERU, verinurad.