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. 2018 Aug 13;9:1808. doi: 10.3389/fimmu.2018.01808

Figure 1.

Figure 1

Accumulation of Foxp3+ CD4+ T cells in diethylnitrosamine (DEN)-treated liver. (A) Percentages of FoxP3+ T cells (gated on CD4+ cells) present within the tumor (T) and the surrounding tissue (S) in wildtype (Klrk1+/+) and NKG2D-deficient (Klrk1−/−) DEN-treated mice, and age-matched control mice (AMC). (B,C) Relative expression of (B) CCL17 and (C) CCL22 mRNA transcripts within tumors (T) and surrounding tissue (S) in wildtype and NKG2D-deficient DEN-treated mice (n ≥ 20) and age-matched control mice (AMC) (n ≥ 8). (D) Ratio of CD8+ T cells to FoxP3+ T cells in wildtype (Klrk1+/+) and NKG2D-deficient (Klrk1−/−) DEN-treated mice, and AMC. Graphs represent the mean ± SEM. Statistical analysis was performed by unpaired Student’s t test, where statistically significant differences between groups are denoted as: *p ≤ 0.05 and **p ≤ 0.01.