Table 1.
Summary of key findings.
| Genetic modification | [PSI +] propagation | Hsp104 curing | |||
|---|---|---|---|---|---|
| Deletion | Overexpression | Strong [PSI+] | Weak [PSI+] | Strong [PSI+] | Weak [PSI+] |
| sis1‐Δ | DROJ1 | Maintained | Lost | Not cured | – |
| sis1‐Δ | sis1–121 | Maintained | Lost | Not cured | – |
| sis1‐Δ | sis1‐ΔG/F | Maintained | Maintained | Not cured | Cured |
| sis1‐Δ | sis1‐ΔG/F, APJ1 | Maintained | – | Partially cured | – |
| 11 cytosolic J‐proteins a | – | Maintained | Maintained | Cured | Cured |
| apj1‐Δ | – | Maintained | Maintained | Partially cured | Cured |
| apj1‐Δ | SIS1 | Maintained | – | Cured | – |
| apj1‐Δ | YDJ1 | – | Maintained | – | Cured |
| – | SIS1 | Maintained | – | Increased curing | – |
| – | APJ1 | Maintained | – | Increased curing | – |
| – | YDJ1 | Maintained | Maintained | Not cured | Cured |
The table summarizes the effects of various genetic modifications (gene deletions/protein overexpression) on the propagation and Hsp104‐mediated curing of strong and weak [PSI +] variants as described in the Results section (see text for additional details).
a. Single deletions: caj1‐Δ, cwc23‐Δj, djp1‐Δ, hlj1‐Δ, jjj1‐Δ, jjj2‐Δ, jjj3‐Δ, swa2‐Δ, xdj1‐Δ, ydj1‐Δ and zuo1‐Δ.