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. 2017 Sep 25;28(4):548–559. doi: 10.1111/bpa.12556

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© 2017 The Authors Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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HS‐Aging neuropathological characteristics on hematoxylin‐eosin‐staining. A. Hippocampal formation without significant pathological findings. Hippocampal subfields are marked. B. A hippocampus with HS‐Aging shows severe atrophy and complete neuron loss, and gliosis in the whole CA1 area and subiculum (arrowheads). Other hippocampal areas appear intact. C. Microglia and pale eosinophilic astrocytes populate the CA1 region in HS‐Aging. Magnifications: (A, B): 2.5x; scale bar (C): 50 μm. DG = Dentate Gyrus, Sub = Subiculum.