Table 1.

Inhibition of COL1A1 promotor of target compounds and cytotoxicity of key compounds.

Code	R1	R2	Inhibition Percentage a	CC50 (μM) b
1	p-CH3C6H4SO2	-	18.5% ± 1.1%	>320
5a	p-CF3C6H4SO2	-	−3.7% ± 3.0%	NT c
5b	C6H5CH2	-	−33.6% ± 10.6%	NT c
5c	p-CH3C6H4CH2	-	−116.2% ± 45.7%	NT c
5d	p-BrC6H4CH2	-	6.4%± 0.9%	NT c
6a	p-CH3C6H4SO2	NH2	21.2% ± 10.4%	>320
6b	p-CH3C6H4SO2	NHCH3	12.8% ± 7.3%	NT c
6c	p-CH3C6H4SO2	NHCH(CH3)2	−84.2% ± 63.1%	NT c
6d	p-CH3C6H4SO2	N(CH3)2	−36.7% ± 17.3%	NT c
6e	p-CH3C6H4SO2	NHPh	69.0% ± 13.5%	82.55
6f	p-CF3C6H4SO2	NH2	−19.0% ± 7.8%	NT c
6g	p-CF3C6H4SO2	NHCH3	6.1% ± 0.8%	NT c
6h	p-CF3C6H4SO2	N(CH3)2	−35.2% ± 2.1%	NT c
6i	C6H5CH2	NH2	47.8% ± 29.0%	>320
6j	C6H5CH2	NHCH3	29.5% ± 6.1%	NT c
6k	C6H5CH2	N(CH3)2	15.2% ± 7.1%	NT c
6l	p-CH3C6H4CH2	NH2	38.7% ± 4.4%	>320
6m	p-CH3C6H4CH2	NHCH3	−29.6% ± 13.6%	NT c
6n	p-CH3C6H4CH2	N(CH3)2	39.7%± 12.3%	>320
6o	p-BrC6H4CH2	NH2	7.8% ± 3.0%	NT c
7a	p-CH3C6H4SO2	NHCOCH3	33.9% ± 9.9%	NT c
7b	p-CF3C6H4SO2	NHCOCH3	−6.0% ± 5.0%	NT c
7c	C6H5CH2	NHCOCH3	12.9% ± 10.6%	NT c
7d	p-CH3C6H4CH2	NHCOCH3	27.0% ± 9.5%	NT c
EGCG	-	-	27.5% ± 7.9%	-
DMSO	-	-	2.9% ± 0	-

^a The inhibition rate of COL1A1 promotor’s activity in LX2 cells; ^b Cytotoxic concentration required to inhibit HepG2 cells cell growth by 50%; ^c Not tested.