Table 4.
Antibacterial activity (MIC [µg/mL]) of compound 1 (isolated from subfraction FIV) and compounds 2–7 obtained by synthesis.
| Comp. | MIC (µg/mL) | |||||||
|---|---|---|---|---|---|---|---|---|
| MSSA | MRSA | SA | SP | SAG | EC | ELM | KP | |
| 1 | 4 | 6.25 | 3.12 | 3.12 | 3.12 | >50 | 50 | 50 |
| 2 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| 3 | 50 | 50 | 50 | 50 | 50 | >50 | >50 | >50 |
| 4 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| 5 | 50 | >50 | 25 | 25 | 50 | >50 | >50 | >50 |
| 6 | 25 | 50 | 50 | 50 | 50 | >50 | 25 | >50 |
| 7 | 12.5 | 50 | 12.5 | 25 | 12.5 | >50 | 12.5 | >50 |
| CEF | 0.5 | 0.5 | 0.5 | 0.25 | 0.25 | 1.9 | 0.5 | 15 |
MSSA = methicillin-sensitive Staphylococcus aureus ATCC 25923, MRSA = methicillin-resistant Staphylococcus aureus ATCC 43300, SA = coagulase negative Staphylococcus aureus 502, SP = Streptococcus pyogenes, SAG = Streptococcus agalactiae, EC = Escherichia coli ATCC 25922, ELM = Escherichia coli LM2, KP = Klebsiella pneumoniae, CEF = cefotaxime.