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Inhibitory potency of compounds 1–4 towards HO-1 and HO-2.
| Compound | IC50 (μM) a | |
|---|---|---|
| HO-1 | HO-2 | |
| (R/S)-1 | 0.40 ± 0.01 b | 32.0 ± 2.2 b |
| (R/S)-2 | 80.0 ± 3.3 | ND c |
| 3 | 28.8 ± 1.4 | 14.4 ± 0.9 |
| (R/S)-4 | 67.6 ± 2.1 | ND c |
| Azalanstat b | 5.3 ± 0.4 | 24.4 ± 0.8 |
a Data are shown as IC50 values in μM ± standard deviation (SD). Values are the mean of triplicate experiments; b Reported in Reference [21]; c ND = not determined.
