Table 5.

Selected in silico ADME profiling for molecules 2 and 3 ^a.

Compound	Absorption		Distribution
	HIA (%)	In Vitro Caco-2 Cell Permeability (nm s−1)	In Vitro PPB (%)	In Vivo BBB Penetration (Cbrain/Cblood)
2	100.0	57.31	94.39	2.01
3	95.86	36.43	100	0.57
4	95.30	26.33	67.75	0.77

^a The properties related to ADME were predicted using PreADMET web-based application (http://preadmet.bmdrc.kr).