Table 4.
Non-compartmental pharmacokinetic parameters obtained for puerarin after its intravenous administration (20 mg/kg, approximately 48 μmol/kg) to DM, HFD and CON rats.
| Pharmacokinetic Parameters | CON | HFD | DM |
|---|---|---|---|
| AUC0–t (μmol·h/L) | 54.84 ± 8.76 | 49.17 ± 8.36 | 35.80 ± 10.04 **,## |
| AUC0–∞ (μmol·h/L) | 56.18 ± 8.39 | 50.07 ± 8.83 | 36.21 ± 10.17 **,## |
| MRT0-t (h) | 1.03 ± 0.08 | 0.97 ± 0.18 | 0.76 ± 0.08 **,# |
| t1/2z (h) | 0.98 ± 0.16 | 0.92 ± 0.17 | 0.75 ± 0.06 |
| CLz (L/h/kg) | 0.87 ± 0.12 | 0.98 ± 0.18 | 1.41 ± 0.36 **,## |
| Cmax (μmol/L) | 75.40 ± 6.63 | 70.34 ± 16.04 | 70.35 ± 9.04 |
| Vz (L/kg) | 1.25 ± 0.32 | 1.29 ± 0.15 | 1.53 ± 0.37 |
AUC0–t, area under the curve of 0 to time t; AUC0–∞, area under the curve of 0 to time infinity; MRT0–t, mean residence time of 0 to time t; t1/2z, half time; CLz, clearance; Cmax, peak concentration; Vz, apparent volume of distribution. Data were expressed as mean ± SD, n = 7 rats, * p <0.05, ** p <0.01 in DM versus CON rats; # p <0.05, ## p <0.01 in DM versus HFD rats.