Table 2.
In vitro cytotoxic activity against nontumorigenic cell lines (WI-38 and MCF-10A), and selectivity index (MCF-10A/ MDA-MB-231) for the active compounds.
| Compound | IC50 (µM) a | Selectivity Index | ||
|---|---|---|---|---|
| Lung WI-38 | Breast MCF-10A | MDA-MB-231 | ||
| 4c | 87.2 ± 5.2 | 112.6 ± 5.9 | 24.1 ± 2.1 | 4.7 |
| 4d | 65.5 ± 4.2 | 80.7 ± 3.4 | 15.7 ± 0.9 | 5.1 |
| 4e | 193.1 ± 10.6 | 89.6 ± 5.1 | 42.6 ± 3.4 | 2.1 |
| 4g | 120.0 ± 7.8 | 141.7 ± 7.9 | 43.6 ± 3.1 | 3.25 |
| 4l | 176.2 ± 11.3 | 157.4 ± 6.8 | 47.2 ± 4.1 | 3.3 |
| 4m | 49.1 ± 1.9 | 73.1 ± 2.7 | 7.6 ± 0.5 | 9.6 |
| 4n | 218.3 ± 13.5 | 154.0 ± 5.2 | 36.3 ± 2.9 | 4.2 |
| 7a | 353.0 ± 17.1 | 233.8 ± 9.6 | 47.2 ± 3.8 | 5.0 |
| 7b | 121.1 ± 6.9 | 183.9 ± 8.0 | 13.2 ± 1.1 | 13.9 |
| 7c | 192.0 ± 10.8 | 242.2 ± 11.5 | 40.3 ± 2.5 | 6.0 |
| 7d | 234.0 ± 15.4 | 250.3 ± 9.8 | 23.5 ± 1.00 | 10.7 |
a IC50 values are the mean ± S.D. of three separate experiments.