Figure 14.

(a) Electrostatic potential map of human GABA-AT active site region. Blue, red and white colors represent regions with positive, negative and neutral electrostatic potential value, respectively; (b) GABA analogues bound into the human GABA-AT catalytic site; (c) (S)-Pregabalin analogues bound into the human GABA-AT catalytic site. (d) (R)-Pregabalin analogues bound into the human GABA-AT catalytic site. (e) (S)-Baclofen analogues bound into the human GABA-AT catalytic site. (f) (R)-Baclofen analogues bound into the human GABA-AT catalytic site. PLP prosthetic group and Fe₂S₂ cofactor are shown as spacefill models.