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. 2018 May 16;23(5):1191. doi: 10.3390/molecules23051191

Table 6.

Chemical structures and pEC50 values of the studied β3-adrenergic ligands a.

Entry Structure EC50 (μM) pEC50
graphic file with name molecules-23-01191-i013.jpg
1 graphic file with name molecules-23-01191-i014.jpg 0.29 6.538
2 graphic file with name molecules-23-01191-i015.jpg 0.18 6.745
3 graphic file with name molecules-23-01191-i016.jpg 0.28 6.553
4 graphic file with name molecules-23-01191-i017.jpg 0.25 6.602
graphic file with name molecules-23-01191-i018.jpg
5 graphic file with name molecules-23-01191-i019.jpg 0.33 6.481
6 graphic file with name molecules-23-01191-i020.jpg 0.28 6.553
7 graphic file with name molecules-23-01191-i021.jpg 2.50 5.602
8 graphic file with name molecules-23-01191-i022.jpg 9.60 5.018
9 graphic file with name molecules-23-01191-i023.jpg 0.65 6.187
10 graphic file with name molecules-23-01191-i024.jpg 0.18 6.745
11 graphic file with name molecules-23-01191-i025.jpg 0.14 6.854
12 graphic file with name molecules-23-01191-i026.jpg 0.13 6.886
13 graphic file with name molecules-23-01191-i027.jpg 0.27 6.569
14 graphic file with name molecules-23-01191-i028.jpg 0.19 6.721
15 graphic file with name molecules-23-01191-i029.jpg 0.26 6.585
graphic file with name molecules-23-01191-i030.jpg
R1 R2
16 (S)-Me H 0.062 7.208
17 H Me 0.28 6.553
18 H Propyl 0.50 6.301
graphic file with name molecules-23-01191-i031.jpg
19 graphic file with name molecules-23-01191-i032.jpg 2.0 5.699
20 graphic file with name molecules-23-01191-i033.jpg 12.0 4.921
21 graphic file with name molecules-23-01191-i034.jpg 130 3.886
22 graphic file with name molecules-23-01191-i035.jpg 9.30 5.032
23 graphic file with name molecules-23-01191-i036.jpg 1.90 5.721
24 graphic file with name molecules-23-01191-i037.jpg 0.44 6.357
graphic file with name molecules-23-01191-i038.jpg 5.854
25 graphic file with name molecules-23-01191-i039.jpg 1.40 6.328
26 graphic file with name molecules-23-01191-i040.jpg 0.47 6.292
27 graphic file with name molecules-23-01191-i041.jpg 0.51 6.398
28 graphic file with name molecules-23-01191-i042.jpg 0.40 5.854
29 graphic file with name molecules-23-01191-i043.jpg 0.27 6.569
30 graphic file with name molecules-23-01191-i044.jpg 0.28 6.553
31 graphic file with name molecules-23-01191-i045.jpg 0.34 6.469
32 graphic file with name molecules-23-01191-i046.jpg 0.10 7.000
33 graphic file with name molecules-23-01191-i047.jpg 0.10 7.000
34 graphic file with name molecules-23-01191-i048.jpg 0.27 6.569
35 graphic file with name molecules-23-01191-i049.jpg 0.16 6.796
36 graphic file with name molecules-23-01191-i050.jpg 0.20 6.699
37 graphic file with name molecules-23-01191-i051.jpg 0.23 6.638
38 graphic file with name molecules-23-01191-i052.jpg 0.23 6.638
39 graphic file with name molecules-23-01191-i053.jpg 0.17 6.770
40 graphic file with name molecules-23-01191-i054.jpg 0.32 6.495
41 graphic file with name molecules-23-01191-i055.jpg 0.65 6.187

a EC50 = Half maximal effective concentration; pEC50 = −logEC50; M = molL−1.