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. 2018 Jun 15;23(6):1453. doi: 10.3390/molecules23061453

Table 1.

Biological activity of benzofuroxane N-oxide derivatives using the microplate Alamar blue assay (MABA) against Mycobacterium tuberculosis strain H37Rv and the low oxygen recovery assay (LORA) against the nonreplicating persistent strain.

graphic file with name molecules-23-01453-i001.jpg

Code R1 R2 MABA MIC (µg/mL) LORA MIC (µg/mL)
T-014 CH3OOC H 7.6 12.98
T-036 CH3OOC CH3O >128 ND
T-046 H H 58.5 46.97
T-063 (CH3)2CHOOC H 1.4 3.04
T-074 CH3CH2CH2OOC H 0.87 4.62
RMP 0.03 0.89
INH 0.12 >128

ND = not determined; RMP: rifampicin; INH: isoniazid.