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. 2018 Jun 8;23(6):1382. doi: 10.3390/molecules23061382

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — Reagents and conditions: (a) ROH, H₂SO₄, reflux; (b) Et₃N, RBr or RCl, acetone, reflux; (c) SOCl₂, reflux, ROH (d) RNH₂ or (CH₃CH₂)₂NH, BOP, Et₃N, CH₂Cl₂, DMF.