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(A,B) Structure alignment between the human 5-LOX structure 3O8Y (crystalized without substrate or inhibitor) and human 5-LOX structure 3V99 (crystalized with arachidonic acid); (C) Amimno acids of human 5-LOX (structure 3V99), conserved in all LOX enzymes (white region), and 5-LOX specific amino acids (yellow area); (D) Structure alignment between the rat 15-LOX, structure 1LOX (crystalized with inhibitor) and human 5-LOX structure 3V99 (crystallized with substrate).
