Figure 11.

(Α) Conserved and 5-LOX specific amino-acids which participate in interactions with substrates and inhibitors at the active site of 3O8Y, indicated in yellow (some of them barely seen because they are hidden inside the cavity); (B) Amino acids interacting with compound 11 in the preferred docking pose to 308Y (center x: −12.5 Å, y: 75.5 Å, z: 0.5 Å, box 35 × 25 × 27). The interacting amino acids are located at the external area of the molecule.