Table 5.
Functional annotation and gene mining of the most relevant Scophthalmus maximus outliers
| LG | SNP | Selection/Geographical region | Genomic region | Gene/Function | Gene mining | Functional enrichment | QTL and previous outliers |
|---|---|---|---|---|---|---|---|
| 01 | 7574_88 |
Divergent Global ATL vs. BLS BAS vs. BLS |
Intergenic | — | AQP1 (R/OS) | Metabolism | G1; VH2 |
| 01 | 5397_68 |
Stabilizing BAS vs. BLS |
Intronic |
ADGRL2 Exocytosis reg. |
DHX30 (AS) | ||
| 02 | 6850_51 |
Divergent Global ATL vs. BAS ATL vs. BLS |
Intronic |
GPM6B Osteoblast differentation |
VEGFC, KTR8, KTR18 (OS) | Metabolism and immune | VH2; V2015 |
| 09 | 1056_25 |
Divergent Global ATL vs. BAS |
Intronic |
MTMR7 Lipid and protein metabolism |
NFIL3 (VH) ILF3, MICALL1, PATL1 (OS) |
Metabolism and immune | AS3; V2015 |
| 09 | 1916_69 |
Divergent Global ATL ATL vs. BAS ATL vs. BLS |
Intergenic | V2015 | |||
| 10 | 5848_28 |
Divergent Global ATL vs. BLS |
Intronic |
HDAC7 Macrophage differentiation |
MTOR (G) | Metabolism and immune | G1 |
| 10 | 7033_88 |
Stabilizing BAS vs. BLS |
Intronic | VSTM2L IG/G‐related | TWIST2 (OS) |
LG, linkage group; Selection: type of selection and geographical region; Gene/Function: official gene symbol and function (IG: immunoglobulin); data mining: relevant genes identified related to growth (G), VHSV resistance (VH), Aeromonas salmonicida resistance (AS), reproduction (R) and osmoregulation (OS); QTLs and previous outliers from 1Sánchez‐Molano et al., 2011; 2Rodríguez‐Ramilo et al., 2014; 3Rodríguez‐Ramilo et al., 2011; V2015: outliers reported by Vilas et al., 2015.