Table 1.
Survival, IFN-1α,β levels, and virus titer of the eight founder CC mice infected with Cl 13 2 × 106 pfu/mL i.v
Mice | Survival, d PI | IFN-1 (24 h PI) | Viral titer, pfu/mL plasma | |||||
IFN-α, ng | IFN-β, pg | 5* | 15* | 30* | 45* | 60* | ||
CC founder | ||||||||
C57BL/6 | >60 | 61 | 540 | 8 × 105 | 1 × 105 | 7 × 104 | 2 × 103 | Nil |
A/J | >60 | 19 | 1,150 | 6 × 105 | 1 × 105 | 7 × 103 | 8 × 102 | Nil |
129S1/SvlmJ | >60 | 36 | 2,016 | 4 × 105 | 2 × 104 | 6 × 103 | 9 × 102 | 8 × 102 |
NOD/LtJ | >60 | 23 | 526 | 2 × 105 | 2 × 105 | 2 × 104 | 7 × 103 | 8 × 103† |
CAST/EiJ | >60 | 9 | 179 | 9 × 104 | 8 × 104 | 3 × 102 | 7 × 102 | Nil |
WSB/EiJ | >60 | 29 | 196 | 8 × 105 | 6 × 104 | 2 × 104 | 2 × 103 | 3 × 103 |
PWK/PhJ | >60 | 22 | 354 | 2 × 105 | 2 × 103 | Nil | Nil | Nil |
NZO/H1Lt | <7 | 56 | 1,267 | 1 × 106 | Dead | — | — | — |
Control | ||||||||
FVB/N | <8 | 55 | 1,604 | 1 × 106 | Dead | — | — | — |
Days PI.
NODs’ titer at day 90 post Cl 13 infection was 6 × 103 pfu/mL plasma. Four to six mice per group. The pfu values indicate the mean for each group of four to five mice. —, mice dead.