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ASIC1a β1 segment confers proton sensitivity on ASIC4. (A) Cartoon illustrating ASIC1a segments that were substituted into ASIC4 (segment 2 circled for clarity). (B) Example currents (Left) and mean peak current amplitude (black columns, Right) in response to pH 4.0 at indicated constructs. (C) Example currents (Left) and mean (±SEM, n = 5–6), normalized responses (Right) to decreasing pH. (Scale bars in B and C: x 5 s, y 0.1 μA.)
