Fig. 5.

StauC is the major contributor to RNAi resistance. (A) Relative StauC mRNA levels in Lepd-SL1 and Lepd-SL1RR cells. Among the 50 RNAi genes tested by qRT-PCR, StauC is the only gene that showed more than twofold difference in expression between Lepd-SL1 and Lepd-SL1RR cells (details are in SI Appendix, Fig. S7). *Significantly different at P ≤ 0.05. (B) Comparison of differential expression of select genes between Lepd-SL1 and Lepd-SL1RR cells measured by qRT-PCR and RNA-seq. The arrow points to the StauC gene, Ld_c7641. Complete names of genes are listed in SI Appendix, Table S2. (C) Testing of 18 differentially expressed genes by RNAi assay, as described in the Fig. 1A legend. Complete names of genes are listed in SI Appendix, Table S3.