Figure 3.
Synthesis of compound 6 and 7. Reagents and conditions: (a) reflux, DMF, CH2Cl2, thionyl chloride, 2 h; (b) 25 °C, 1 eq amantadine (1), CHCl3, trietylamine, 2 h or MW, 100 °C, 150 W, 250 psi, 30 min.
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