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. 2018 Jul 10;23(7):1678. doi: 10.3390/molecules23071678

Table 1.

Reaction conditions and outcomes of the conventional methods compared to the microwave-assisted methods (MWAM).

Compound Time % Yields
Conventional MWAM Conventional MWAM
3 48 h 1 30 min 2 25 3 78 3
6 2 h 10 min 25 4 64 4
7 2 h 10 min 40 4 82 4

1 A 1:1 ratio of starting materials 1 and 2 was used. 2 A 2:1 ratio of starting materials 1 and 2 was used. 3 Percantage yield was calculated from the amount of 4-(chlorosulfonyl)benzoic acid (2) used. 4 Percentage yield was calculated from the amount of amantadine (1) used.