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. 2018 Jun 13;23(6):1430. doi: 10.3390/molecules23061430

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Relaxant effect of limonene, carveol, and perillyl alcohol on pharmacomechanical coupling. Sustained contractions induced by PHE (0.1 μM) in endothelium-intact (A) and endothelium-denuded (B) rat aortic rings. Results are shown as means ± SEM. * indicates statistical difference of limonene, carveol, and perillyl alcohol compared to the control (p < 0.05, two way ANOVA and Holm-Sidak test). # indicates statistical difference between limonene (600 μM) compared to the control (p < 0.05, one-way ANOVA and Holm-Sidak test). Each control consisted of the same concentration of vehicle as in the experimental case, but without the experimental substance.