Table 1.
Biodistribution data obtained in KB and IGROV-1 tumor-bearing mice, 4 h after injection of [177Lu]folate with and without pre-injected pemetrexed (PMX). Data are shown as % IA/g tissue, representing the average ± S.D.
| [177Lu]cm13 | ||||
|---|---|---|---|---|
| - | PMX (1) | - | PMX (1) | |
| 4 h p.i. | 4 h p.i. | 4 h p.i. | 4 h p.i. | |
| Tissue | KB | KB | IGROV-1 | IGROV-1 |
| n = 5 | n = 5 | n = 4 | n = 4 | |
| Blood | 7.32 ± 0.85 | 9.13 ± 0.89 | 7.88 ± 1.70 | 10.8 ± 1.43 |
| Lung | 4.33 ± 0.44 | 4.92 ± 0.39 | 4.47 ± 0.97 | 6.14 ± 0.97 |
| Spleen | 1.51 ± 0.15 | 1.45 ± 0.06 | 1.74 ± 0.15 | 2.16 ± 0.45 |
| Kidneys | 26.5 ± 1.20 | 15.8 ± 2.60 **** | 26.9 ± 2.90 | 16.9 ± 3.10 *** |
| Stomach | 1.37 ± 0.35 | 1.41 ± 0.19 | 1.58 ± 0.47 | 1.83 ± 0.39 |
| Intestines | 1.29 ± 0.42 | 1.38 ± 0.32 | 1.10 ± 0.18 | 1.12 ± 0.20 |
| Liver | 3.88 ± 0.49 | 3.31 ± 0.43 | 3.27 ± 0.49 | 3.38 ± 0.56 |
| Muscle | 1.92 ± 0.25 | 1.55 ± 0.28 | 1.17 ± 0.43 | 1.28 ± 0.38 |
| Bone | 1.55 ± 0.10 | 1.67 ± 0.24 | 1.38 ± 0.30 | 1.57 ± 0.25 |
| Tumor | 22.4 ± 4.50 | 17.6 ± 0.90 *** | 31.5 ± 5.60 | 29.2 ± 8.80 |
| Salivary glands | 6.78 ± 0.57 | 5.84 ± 1.25 | 6.17 ± 0.49 | 6.18 ± 0.88 |
(1) PMX (400 µg/mouse) was injected 1 h prior to the [177Lu]folate; Statistical significance is indicated by asterisks (statistically significant difference between uptake in the tissue of control mice and PMX injected mice.) *** p ≤ 0.001; **** p ≤ 0.0001).