Table 2.

Biodistribution data obtained in KB tumor-bearing mice, 24 h after injection of [¹⁷⁷Lu]folate with and without pre- and post-injected pemetrexed (PMX). Data are shown as % IA/g tissue, representing the average ± S.D.

	[177Lu]cm13
	-	PMX (1)	PMX (2)	PMX (3)
	24 h p.i.	24 h p.i.	24 h p.i.	24 h p.i.
Tissue	KB	KB	KB	KB
	n = 4	n = 5	n = 4	n = 4
Blood	1.28 ± 0.23	1.39 ± 0.14	1.37 ± 0.17	1.31 ± 0.14
Lung	1.74 ± 0.45	1.69 ± 0.22	1.66 ± 0.15	1.60 ± 0.35
Spleen	0.69 ± 0.14	0.79 ± 0.13	0.80 ± 0.13	0.72 ± 0.15
Kidneys	30.9 ± 3.90	24.7 ± 5.70 **	21.8 ± 0.70 ****	21.0 ± 4.70 ****
Stomach	0.77 ± 0.19	0.70 ± 0.20	0.80 ± 0.14	0.63 ± 0.21
Intestines	0.27 ± 0.07	0.47 ± 0.14	0.30 ± 0.07	0.34 ± 0.06
Liver	2.46 ± 0.16	1.91 ± 0.44	2.04 ± 0.57	2.05 ± 0.05
Muscle	1.56 ± 0.10	1.31 ± 0.25	1.17 ± 0.20	1.50 ± 0.49
Bone	1.09 ± 0.31	0.97 ± 0.15	0.85 ± 0.06	0.95 ± 0.16
Tumor	18.6 ± 6.80	22.1 ± 3.60	22.4 ± 3.20	20.9 ± 5.10
Salivary glands	4.18 ± 0.62	3.71 ± 0.33	3.39 ± 0.30	3.86 ± 0.44

⁽¹⁾ PMX (400 µg/mouse) was injected 1 h prior to the [¹⁷⁷Lu]folate; ⁽²⁾ PMX (twice 400 µg/mouse) was injected 1 h prior to the [¹⁷⁷Lu]folate and 3 h after [¹⁷⁷Lu]folate; ⁽³⁾ PMX (twice 400 µg/mouse) was injected 1 h prior to the [¹⁷⁷Lu]folate and 7 h after [¹⁷⁷Lu]folate. Statistical significance is indicated with asterisks (statistically significant difference between uptake in the tissue of control mice and PMX injected mice). ** p ≤ 0.01; **** p ≤ 0.0001).