Table 1.

Antiparasitic activity in L. major-luc promastigotes, and cytotoxicity to intraperitoneal mouse macrophages (IPΦ) or monkey kidney cells (LLC-MK2) of 5A and analogs. EC₅₀ Median effective concentration. ± values are the estimated EC₅₀ interval. CC₅₀ Median cytotoxic concentration. ± values are the estimated CC₅₀ interval S.I. Selective Index (CC₅₀ mammalian cells)/(EC₅₀ in L. major-luc promastigotes).

Compound	Leishmania major-luc	Mammalian Cells	Mammalian Cells
	Promastigotes	IPΦ	LLC-MK2
	EC50 (μM)	CC50 (μM) [S.I.]	CC50 (μM) [S.I.]
5A	~0.3410	~ 10.40 [30.50]	17.69 ± 1.12 [52.85]
5B	5.98 ± 1.72	N/A	N/A
5C	4.73 ± 0.69	N/A	N/A
5D	0.09 ± 0.02	27.89 ± 3.19 [310]	>80
5E	0.78 ± 0.11	16.59 ± 1.52 [21.27]	80 ± 4.45 [102.56]
5F	>12.50	N/A	N/A
5G	>12.50	N/A	N/A
5H	3.05 ± 0.47	N/A	N/A
5I	5.5 ± 1.80	N/A	N/A