Table 3.

Data from radioligand binding assays.

Cmpd	Source	Binding Site	Ligand	IC50 [µM]	Ki [µM]	Stimulation [%]	c [µM]	Ref.
4	Leonurus japonicus	GABA/muscimol	[3H]gabazine	15,000				[24]
19	Aconitum leucostomum	GABA/muscimol	[3H]muscimol	7.06				[31]
218		GABA/muscimol	[3H]GABA		64 ± 5			[160]
2	Colchicum szovitsii	benzodiazepine	[3H]flunitrazepam			25% of 10 µM allopregnanolone	10	[22]
3	Colchicum szovitsii	benzodiazepine	[3H]flunitrazepam			25% of 10 µM allopregnanolone	10	[22]
4	Leonurus japonicus	benzodiazepine	[3H]flumazenil	123,000				[24]
16	Oceanapia sp.	benzodiazepine	[3H]diazepam			39	25	[30]
17	Oceanapia sp.	benzodiazepine	[3H]diazepam			32	25	[30]
18	Oceanapia sp.	benzodiazepine	[3H]diazepam			30	25	[30]
34	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam		7.81 ± 1.81			[42]
35	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam		4.20 ± 0.27			[42]
36	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam		0.21 ± 0.10			[42]
37	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam		0.56 ± 0.07			[42]
38	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam		0.027 ± 0.003			[42]
39	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	6.42 ± 0.95				[41]
40	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam		0.0075 ± 0.004			[42]
41	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	0.28 ± 0.076				[41]
42	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam		2.64 ± 0.36			[42]
43	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam		0.034 ± 0.001			[42]
44	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam		9.46 ± 1.45			[42]
45	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	0.69 ± 0.12	0.64 ± 0.26			[41,42]
46	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	1.26 ± 0.24	1.52 ± 0.13			[41,42]
47	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	0.36 ± 0.095	0.20 ± 0.05			[41,42]
48	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	0.008 ± 0.0002	0.0061 ± 0.0001			[41,42]
49	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	0.31 ± 0.088				[41]
50	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam		0.0038 ± 0.005			[42]
51	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam		5.58 ± 0.02			[42]
52	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	21.0 ± 1.79				[41]
53	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	21.4 ± 1.42				[41]
54	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	10.1 ± 1.68				[41]
55	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	>100				[41]
56	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	0.14 ± 0.01	0.89 ± 0.06			[41,42]
57	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	22.6 ± 1.30				[41]
58	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	12.5 ± 1.58				[41]
59	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	1.27 ± 0.08				[41]
60	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	6.80 ± 1.18				[41]
61	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	32.8 ± 1.51				[41]
62	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	45.7 ± 2.48				[41]
63	Tanacetum parthenium	benzodiazepine	[3H]flumazenil	12	9			[60]
63	Salvia officinalis	benzodiazepine	[3H]flumazenil	30 ± 4				[65]
63	Rhus pyroides	benzodiazepine	[3H]flumazenil	10.0 ± 1.18				[59]
63	Matricaria recutita	benzodiazepine	[3H]flunitrazepam		4			[58]
66	Artemisia herba-alba	benzodiazepine	[3H]flumazenil	8				[66]
66	Salvia officinalis	benzodiazepine	[3H]flumazenil	1.3 ± 0.2				[65]
67	Salvia officinalis	benzodiazepine	[3H]flumazenil	350 ± 37				[65]
68	Salvia coerulea	benzodiazepine	[3H]flunitrazepam		200			[67]
68	Salvia coerulea	benzodiazepine	[3H]zolpidem		20			[67]
69	Artemisia herba-alba	benzodiazepine	[3H]flumazenil	100				[66]
70	Artemisia herba-alba	benzodiazepine	[methyl-3H]DZP	1.3				[68]
71	Artemisia herba-alba	benzodiazepine	[methyl-3H]DZP	22.7				[68]
78	Hypericum perforatum	benzodiazepine	[3H]flunitrazepam	0.0149				[74]
78	Searsia pyroides	benzodiazepine	[3H]flunitrazepam		37			[59]
79	Searsia pyroides	benzodiazepine	[3H]flunitrazepam		28			[59]
85	Mentha aquatica	benzodiazepine	[3H]flumazenil	2600				[78]
87	Scuttelaria baicalensis	benzodiazepine	[3H]flunitrazepam	21.4 ± 1.32				[41]
91	Glycyrrhiza glabra	benzodiazepine	[3H]flumazenil		1.63			[80]
98		benzodiazepine	[3H]flunitrazepam		0.453			[84]
121	Angelica dahurica	benzodiazepine	[3H]diazepam	8.0 ± 0.8				[98]
122	Angelica dahurica	benzodiazepine	[3H]diazepam	0.36 ± 0.03				[98]
123	Angelica dahurica	benzodiazepine	[3H]diazepam	12 ± 3				[98]
154		benzodiazepine	[3H]flunitrazepam	74.44				[120]
156		benzodiazepine	[3H]flunitrazepam	15.69				[120]
157		benzodiazepine	[3H]flunitrazepam	90.02				[120]
160		benzodiazepine	[3H]flunitrazepam	130.9				[124]
181	Cyperus rotundus	benzodiazepine	[3H]flunitrazepam		105.0 ± 1.60			[134]
186	Mentha aquatica	benzodiazepine	[3H]flumazenil	190,000				[78]
199	Salvia miltiorrhiza	benzodiazepine	[3H]flunitrazepam	0.3				[146]
200	Salvia officinalis	benzodiazepine	[3H]flumazenil	7.2 ± 0.7				[65]
201	Salvia officinalis	benzodiazepine	[3H]flumazenil	0.8 ± 0.1				[65]
205	Aloysia virgata	benzodiazepine	[3H]flumazenil		111 ± 13			[150]
206	Aloysia virgata	benzodiazepine	[3H]flumazenil		56 ± 19			[150]
2	Colchicum szovitsii	TBPS/picrotoxin	[35S]TBPS			25% of 10 µM allopregnanolone	10	[22]
3	Colchicum szovitsii	TBPS/picrotoxin	[35S]TBPS			25% of 10 µM allopregnanolone	10	[22]
7	Corydalis cava	TBPS/picrotoxin	[3H]bicuculline			121 ± 2	0.1	[26]
8	Corydalis cava	TBPS/picrotoxin	[3H]bicuculline			149 ± 2	0.01	[26]
9	Corydalis cava	TBPS/picrotoxin	[3H]bicuculline			130 ± 3	0.1	[26]
10	Corydalis cava	TBPS/picrotoxin	[3H]bicuculline			146 ± 7	0.01	[26]
11	Corydalis cava	TBPS/picrotoxin	[3H]bicuculline			147 ± 3	0.1	[26]
24	Cicuta virosa	TBPS/picrotoxin	[3H]EBOB	0.54 ± 0.03				[37]
25	Cicuta virosa	TBPS/picrotoxin	[3H]EBOB	2.01 ± 0.09				[37]
26	Cicuta virosa	TBPS/picrotoxin	[3H]EBOB	1.15 ± 0.09				[37]
27	Cicuta virosa	TBPS/picrotoxin	[3H]EBOB	6.01 ± 0.29				[37]
28	Cicuta virosa	TBPS/picrotoxin	[3H]EBOB	7.87 ± 0.83				[37]
65	Valeriana jatamansi	TBPS/picrotoxin	[35S]TBPS		0.50 ± 0.17			[63]
79	Rhus parviflora	TBPS/picrotoxin	[35S]TBPS	0.149	0.091			[75]
80	Rhus parviflora	TBPS/picrotoxin	[35S]TBPS	0.073	0.045			[75]
81	Rhus parviflora	TBPS/picrotoxin	[35S]TBPS	0.455	0.280			[75]
145	Ecklonia cava	TBPS/picrotoxin	[35S]TBPS	7.180	4.419			[80]
146	Ecklonia cava	TBPS/picrotoxin	[35S]TBPS	1.739	1.070			[80]
147	Ecklonia cava	TBPS/picrotoxin	[35S]TBPS	4.991	3.072			[80]
148	Ecklonia cava	TBPS/picrotoxin	[35S]TBPS	2.422	1.491			[80]
154		TBPS/picrotoxin	[35S]TBPS	13 ± 4				[117]
155		TBPS/picrotoxin	[35S]TBPS	37 ± 8				[117]
197	Illicium anisatum	TBPS/picrotoxin	[3H]EBOB	0.43				[144]
212	Ginkgo biloba	TBPS/picrotoxin	[35S]TBPS	39				[154]