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. 2018 Aug 13;9:1755. doi: 10.3389/fimmu.2018.01755

Figure 1.

Figure 1

Increased Th17 cells but no change of Treg cells in primary Sjögren’s syndrome (pSS) patients. (A,B) The percentages of IL-17+CD4+ T cells in the PBMCs from healthy donors or pSS patients were determined by flow cytometry. Representative plot (A) and histogram analysis (B) were shown. (C) The amount of Il17a mRNA in PBMCs was determined by q-PCR. (D,E) The percentages of Foxp3+CD4+ T cells in the PBMCs were determined by flow cytometry. Representative plot (D) and histogram analysis (E) were shown. (F) The amount of Foxp3 mRNA in PBMCs from healthy donors or pSS patients was determined by q-PCR. (G) IL-17A levels in the minor salivary gland (MSG) from Sicca or pSS patients were determined by immunohistochemistry. (H–I) The amounts of Il17a (H) and Foxp3 mRNA (I) were determined by q-PCR. (J) Immunofluorescence staining of CD4 and IL-17A in the MSG specimens from pSS patients. Representative images are shown (400×). **p < 0.01, ***p < 0.001.