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Synthesis of G114 (2). Reagents and conditions: (a) Fmoc–Leu–OH, DIPEA, DCM, rt, 3.5 h; (b) solid-phase peptide synthesis (SPPS) of non-acetylated peptide on a microwave peptide synthesizer; (c) Ac2O–DIPEA–NMP (1:2:3), rt, 2 × 10 min; (d) 20% HFIP–DCM, 3 × 30 min, rt; (e) 5, PyBOP, DIPEA, DCM, DMF (few drops), rt, 13 h; (f) TFA (with a few drops of H2O added), rt, 24 h.
