Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jun 15;23(6):1463. doi: 10.3390/molecules23061463

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Scheme 4 — Continuous solid-phase synthesis (SPS) of Mipsagargin (6). Reagents and conditions: (a) Fmoc-Glu-OtBu, DIPEA, DCM, 3 h; (b) Fmoc-Glu-OtBu, PyBOP, DIPEA, DMF, 16 h; (c) 20% piperidine–DMF, 2 × 20 min; (d) Boc-Asp(All)-OH, PyBOP, DIPEA, DMF, 18 h; (e) Me₂N–BH₃ in DCM, Pd(PPh₃)₄ in DCM, 6 h; (f) 5, PyBOP, DIPEA, DCM, 18 h; (g) TFA–DCM (1:1 with a few drops of H₂O added), 1 h; all reactions were carried out at rt.