Table 2.

Inhibitory activities of 15a–15k against PGAM1.

Entry	Compounds	R1	IC50 (μM) *
1	9m	8-OH	5.5 ± 1.1
2	15a	H	14.3 ± 0.8
3	15b	5-OMe	6.5 ± 1.3
4	15c	5-Me	8.6 ± 3.1
5	15d	7-OMe	4.6 ± 0.8
6	15e	7-Me	8.0 ± 2.1
7	15f	7-Cl	3.5 ± 1.0
8	15g	7-F	13.7 ± 5.5
9	15h	7-NO2	2.1 ± 0.2
10	15i	7-OH	6.4 ± 1.0
11	15j	7-OAc	2.7 ± 0.5
12	PGMI-004A		13 ± 0.1

* All IC₅₀ values are reported as means ± SD from three determinations.