Table 2.
Examples of polyamides targeting oncogenic transcription factors.
| Transcription Factor Family | Transcription Factor Target | Tumor Model | References |
|---|---|---|---|
| AT-rich binder | TBP | - | [323] |
| LEF-1 | Colon | [324] | |
| Hormone/Steroid receptor | estrogen receptor | Breast | [325] |
| androgen receptor | Prostate | [326,327] | |
| glucocorticoid receptor | - | [327,328] | |
| B-Zip | GCN-4 | - | [328,329] |
| AP-1 | - | [330,331,332] | |
| ETS-domain | ETS-1 | - | [333,334] |
| EVI1 | Leukemia | [335] | |
| ELK-1 | Breast | [336] | |
| PU.1/SPI1 | - | [337] | |
| Zn-Finger | TFIIIA | - | [338,339] |
| Zif268 | - | [340] | |
| Others | NF-Y | Lung | [341,342,343,344,345] |
| NFκB | Lung, Osteosarcoma | [346,347] | |
| HIF1 | Kidney, Glioblastoma, Multiple myeloma | [348,349,350,351] | |
| c-MYC | Osteosarcoma, Burkitt’s lymphoma | [352,353] | |
| OCT1 | Prostate | [354] | |
| RUNX | Acute myeloid leukemia | [355] | |
| E2F1 | Chronic myeloid leukemia | [355] |