Table 3.
Examples of mithramycins deregulated genes that occurs upon inhibition of SP1 transcription factor.
| Type of Protein | Gene Promoter | Tumor Model | References |
|---|---|---|---|
| Transcription factors | c-MYC | Cervix carcinoma | [386] |
| FoxM1 | Liver | [387] | |
| KLF5 | Breast | [388,389] | |
| SNAI1 | Salivary adenoid cystic carcinoma | [390] | |
| SP1 | |||
| Regulators of cell proliferation | CDKN1A | Liver | [391] |
| Survivin | Colon | [392] | |
| Ki-67 | - | [393] | |
| CRABP1 | Ovary | [394] | |
| Tumor suppressors | KCNMA1 | Ovary | [394] |
| p73 | Lung | [395] | |
| Apoptotic genes | XIAP | Ovary | [394] |
| BAK1 | Liver | [396] | |
| Secreted factors | Collagen-alpha 1 | - | [397] |
| Tissue factor | - | [397] | |
| MUC2 | Colon | [398] | |
| TGFBI | Lung, Breast | [399] | |
| ECRG4 | Leukemia | [400] | |
| Membrane associated proteins (receptors, transporters) | Androgen receptor | Prostate | [401] |
| ABCG2 | Lung | [402] | |
| FZD1 | - | [403] | |
| Metabolic enzymes | Dihydrofolate reductase | Breast | [404] |
| Carbonic anhydrase IX | - | [405] | |
| Cell differentiation | MSI2 | Lung | [406] |
| Cell movement | KIF2C kinesin | Colon | [407] |