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. 2018 Aug 13;9:365. doi: 10.3389/fpsyt.2018.00365

Figure 2.

Figure 2

Sex differences in resting-state modularity revealed using the probability associated community estimation (PACE). Slices obtained from 100-ROI, 200-ROI, and 300-ROI resolutions using the Human Connectome Project (HCP) data. At PACE Level 1, two brain modules are extracted, here shown as the red community (corresponding to task positive network or TPN) and the green community (corresponding to task negative community or TNN). Mixing of communities is shown in the overlay in yellow (since HCP parcellation is ICA-based, components may overlap thus resulting in the mixing of TPN and TNN). As expected, with increasing spatial resolution (from 100 to 300 ROIs), sex differences also become more significant (for both 200-ROI and 300-ROI resolution p < 0.0001; significant after Bonferroni correction with a p value cut-off 0.05/3). Differences between the sexes (boxed) include precuneus, hippocampus, and amygdala. MNI coordinates: x = 12, y = −14, z = 22.