Table 1.
Potency of tested oximes to reactivate POX-inhibited erythrocyte HssAChE and plasma HssBChE at concentrations 100 µM and 10 µM. (%, mean value of three independent determinations; time of reactivation by HssAChE reactivators = 10 min; pH 7.4; temperature 25 °C).
| Reactivator | Reactivation (%) | |||||||
|---|---|---|---|---|---|---|---|---|
| HssAChE | HssBChE | |||||||
| 100 µM | 10 µM | 100 µM | 10 µM | |||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
| pralidoxime | 18.2 | 0.7 | 1.3 | 0.7 | 5.5 | 0.1 | 1.0 | 0.2 |
| obidoxime | 96.9 | 0.7 | 59.4 | 0.7 | 9.9 | 0.3 | 2.2 | 0.3 |
| HI-6 | 16.1 | 0.0 | 3.9 | 0.7 | 2.3 | 0.2 | 0.8 | 0.4 |
| K131 | 1.7 | 0.0 | 1.1 | 1.1 | 0.3 | 0.3 | 0.3 | 0.3 |
| K142 | 7.0 | 1.0 | 3.0 | 0.8 | 1.1 | 0.2 | 0.6 | 0.3 |
| K153 | 9.8 | 1.0 | 2.3 | 1.5 | 2.0 | 0.5 | 0.3 | 0.3 |