Table 1.
IC50 values for antitumor screening of target derivatives. The data shown are the mean ± standard deviation (SD) of at least three independent experimentations.
| Compound | IC50 (µM) | 3rd Position Substitution | |
|---|---|---|---|
| MCF-7 | MDA-MBA-231 | ||
| A | 24.97 ± 1.61 | 16.34 ± 1.21 | Glycine |
| B | 68.49 ± 3.27 | 42.93 ± 2.64 | l-alanine |
| C | 1.16 ± 0.05 | 3.45 ± 0.21 | l-valine |
| D | 11.28 ± 1.25 | 7.49 ± 0.42 | l-isoleucine |
| E | 12.44 ± 5.73 | 0.43 ± 0.02 | l-glutamine |
| F | 1.93 ± 0.08 | 12.46 ± 5.88 | l-cysteine |
| G | 0.44 ± 0.01 | 24.67 ± 1.7 | l-phenylalanine |
| H | 1.28 ± 0.03 | 11.96 ± 1.33 | l-proline |
| Erlotinib | 1.14 ± 004 | 2.55 ± 0.19 | |