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Representative MRM chromatograms of peimine (a), peiminine (b) and IS (c) in beagle dog plasma samples. Blank beagle dog plasma (1), a spiked plasma sample with the analytes at LLOQ (2), a blank plasma with IS and analytes at low QC levels (1.976 ng/mL for peimine, 1.960 ng/mL for peiminine) (3), a plasma sample taken 2 h after oral administration of 1.0 g/kg Fritillaria ussuriensis Maxim powder (4) and 1.0 g/kg Fritillaria thunbergii Miq powder (5).
