Robotnikinin |
SHH |
binds to the N terminal part of SHH |
[147] |
RU-SKI 43 |
SHH |
inhibits SHH palmitoylation |
[148] |
5E1 antibody |
SHH |
binds to the N terminal part of SHH |
[149] |
GDC-0449 (Vismodegib) |
SMO |
antagonist of SMO |
[150] |
LDE225 (Sonidegib) |
SMO |
antagonist of SMO |
[151] |
IPI 926 (Saridegib) |
SMO |
cyclopamine-derived antagonist of SMO |
[152] |
LY2940680 (Taladegib) |
SMO |
antagonist of SMO |
[153] |
PF-04449913 (Glasdegib) |
SMO |
antagonist of SMO |
[154] |
Cyclopamine |
SMO |
antagonist of SMO, blocks conformational change of SMO into the active form |
[155] |
TAK-441 |
SMO |
antagonist of SMO |
[156] |
CUR61414 |
SMO |
antagonist of SMO |
[157] |
Jervine |
SMO |
antagonist of SMO, blocks conformational change of SMO into the active form |
[158] |
BMS-833923 |
SMO |
antagonist of SMO |
[159] |
GANT61, GANT58 |
GLI |
blocks binding of GLIs to DNA |
[101] |
Glabrescione B |
GLI |
blocks binding of GLIs to DNA |
[107] |
Arsenic trioxide |
GLI |
reduces stability of GLI2 |
[115] |
Pirfenidone |
GLI |
reduces stability of GLI2 |
[64] |
HPI 1–4 |
GLI |
influence stability, degradation rate, and trafficking of GLIs to the primary cilium |
[125] |
Pyrvinium |
GLI |
induces proteosomal degradation of GLIs through CK1–mediated phosphorylation |
[127] |
Imiquimod |
GLI |
induces proteosomal degradation of GLIs through ADORA/PKA–mediated phosphorylation |
[128] |
Nanoquinacrine |
GLI |
increased expressions of GSK3β, PTEN and binds to and destabilizes GLI1-DNA complex |
[129] |