Table 1.
List of Hh pathway inhibitors.
| Inhibitor Name | Target | Mode of Action | Reference |
|---|---|---|---|
| Robotnikinin | SHH | binds to the N terminal part of SHH | [147] |
| RU-SKI 43 | SHH | inhibits SHH palmitoylation | [148] |
| 5E1 antibody | SHH | binds to the N terminal part of SHH | [149] |
| GDC-0449 (Vismodegib) | SMO | antagonist of SMO | [150] |
| LDE225 (Sonidegib) | SMO | antagonist of SMO | [151] |
| IPI 926 (Saridegib) | SMO | cyclopamine-derived antagonist of SMO | [152] |
| LY2940680 (Taladegib) | SMO | antagonist of SMO | [153] |
| PF-04449913 (Glasdegib) | SMO | antagonist of SMO | [154] |
| Cyclopamine | SMO | antagonist of SMO, blocks conformational change of SMO into the active form | [155] |
| TAK-441 | SMO | antagonist of SMO | [156] |
| CUR61414 | SMO | antagonist of SMO | [157] |
| Jervine | SMO | antagonist of SMO, blocks conformational change of SMO into the active form | [158] |
| BMS-833923 | SMO | antagonist of SMO | [159] |
| GANT61, GANT58 | GLI | blocks binding of GLIs to DNA | [101] |
| Glabrescione B | GLI | blocks binding of GLIs to DNA | [107] |
| Arsenic trioxide | GLI | reduces stability of GLI2 | [115] |
| Pirfenidone | GLI | reduces stability of GLI2 | [64] |
| HPI 1–4 | GLI | influence stability, degradation rate, and trafficking of GLIs to the primary cilium | [125] |
| Pyrvinium | GLI | induces proteosomal degradation of GLIs through CK1–mediated phosphorylation | [127] |
| Imiquimod | GLI | induces proteosomal degradation of GLIs through ADORA/PKA–mediated phosphorylation | [128] |
| Nanoquinacrine | GLI | increased expressions of GSK3β, PTEN and binds to and destabilizes GLI1-DNA complex | [129] |