Table 2.
Data on accuracy and precision obtained from the analysis of quality control samples containing rosuvastatin and metformin (n = 3 runs; five replicates per run).
| Compound | Concentration (ng mL−1) | ||
|---|---|---|---|
| Metformin | |||
| Added Concentration | 62.5 | 500 | 5000 |
| Run 1 (mean ± s.d.) | 63.9 ± 6.1 | 489 ± 29 | 5045 ± 352 |
| Run 2 (mean ± s.d.) | 64.3 ± 5.1 | 42.9 ± 8.3 | 4698 ± 143 |
| Run 3 (mean ± s.d.) | 60.1 ± 6.0 | 488 ± 39 | 4768 ± 232 |
| Overall mean | 62.7 | 497.9 | 4837 |
| Intra-day CV (%) a | 9.1 | 7.6 | 5.3 |
| Inter-day CV (%) a | 1.8 | 1.0 | 3.0 |
| Overall accuracy Er% b | 0.4 | −0.4 | −3.3 |
| Rosuvastatin | |||
| Added Concentration | 2 | 10 | 100 |
| Run 1 (mean ± s.d.) | 2.31 ± 0.21 | 9.41 ± 0.33 | 104.1 ± 6.6 |
| Run 2 (mean ± s.d.) | 2.12 ± 0.22 | 9.61 ± 0.89 | 96.5 ± 5.7 |
| Run 3 (mean ± s.d.) | 2.01 ± 0.21 | 10.81 ± 0.46 | 96.2 ± 9.1 |
| Overall mean | 2.1 | 9.9 | 98.9 |
| Intra-day CV (%) a | 8.5 | 6.2 | 7.3 |
| Inter-day CV (%) a | 4.4 | 7.1 | 3.0 |
| Overall accuracy Er% b | 7.0 | −1.0 | −1.1 |
a Intra- and inter-assay coefficient of variations as calculated by ANOVA. b Relative percentage error.