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(A) Structures of two Buxus sempervirens alkaloids, 18 and 19. (B) 3D-models of 18 and 19 superposed with 3, (C) O-tigloylcyclovirobuxein B (18) and (C) cyclovirobuxein B (19). (B–D) show the contour maps of the CoMFA model for anti-Tbr activity (compare Figure 3) and the sterically unfavorable interaction of 18 explaining its low activity is marked.
