Table 3. Associations Between Methylation Status of Top Tumor Necrosis Factor α Cytosine-Phosphate-Guanine Sites and Neighboring Gene Expression.
| Transcript |
P Value in RS (n = 750) |
P Value in FHS (n = 2262) |
P Value in KORA (n = 726) |
Direction of Association |
|---|---|---|---|---|
| CpG site cg16411857a | ||||
| NLRC5 | .0002 | 2.56 × 10−8 | .16 | Negative |
| CpG site cg07839457a | ||||
| NLRC5 | 2.10 × 10−7 | 1.85 × 10−8 | .44 | Negative |
| CpG site cg00959259b | ||||
| DTX3L | 1.07 × 10−6 | 1.80 × 10−9 | .80 | Negative and positive |
| PARP9 | 2.86 × 10−22 | 2.58 × 10−13 | .81/.07c | Negative |
| PARP14 | 9.21 × 10−23 | 6.51 × 10−17 | NAd | Negative and uncertain |
| DTX3L | 2.91 × 10−7 | 2.13 × 10−6 | 0.61 | Negative |
| KPNA1 | .0003 | .00004 | NAd | Positive and uncertain |
| CpG site cg08122652b | ||||
| PARP9 | 1.04 × 10−25 | 1.09 × 10−9 | 0.12/0.26c | Negative |
| PARP14 | 1.25 × 10−24 | 8.48 × 10−15 | NA | Negative and uncertain |
Abbreviations: FHS, Framingham Heart Study; KORA, Kooperative Gesundheitsforschung in der Region Augsburg Study; NA, not available; RS, Rotterdam Study.
a
On chromosome 16.
b
On chromosome 3.
c
Two probes (ILMN_1731224 and ILMN_2053527) corresponded to PARP9 in KORA.
d
Reliable measurements of this gene's expression were not available in the KORA cohort.