. 2018 Apr 4;3(6):463–472. doi: 10.1001/jamacardio.2018.0510

Table 4. Associations Between Incident Coronary Heart Disease and Methylation Status of Top Tumor Necrosis Factor α Cytosine-Phosphate-Guanine Sites in a Meta-analysis of 8 Cohorts With 1895 Disease Events and 11 641 Participants.

Site	Chromosome	Position^a	Gene	Hazard Ratio^b (95% CI)	P Value
cg16411857	16	57023191	NLRC5	0.86 (0.78-0.95)	.003
cg07839457	16	57023022	NLRC5	0.89 (0.80-0.94)	3.1 × 10⁻⁵
cg00959259	3	122281975	DTX3L; PARP9	0.91 (0.84-0.97)	.002
cg08122652	3	122281939	DTX3L; PARP9	0.81 (0.74-0.89)	2.0 × 10⁻⁵

^{^a}

Positions are per Human genome 19/Genome Reference Consortium Human Build 37 from University of California Santa Cruz.

^{^b}

Hazard ratios are per 10% increase in methylation.