Table 3.
Correlations coefficients of MtDNA copy number with functional performance measures, according to ABI value.
| ABI < 0.60 (n=l2) | ABI 0.60–0.90 (n=2l) | No PADa (n=9) | Interaction term for PAD status and association of MtDNA copy number with functional performance | |
|---|---|---|---|---|
| Six-minute walk test | ||||
| Pearson correlation coefficient with mitochondrial DNA copy number | −0.344 | −0.057 | 0.653 | <0.00l |
| p-value | 0.273 | 0.808 | 0.057 | |
| Four-meter walking velocity at usual pace | ||||
| Pearson correlation coefficient with mitochondrial DNA copy number | −0.264 | −0.003 | 0.579 | 0.0l5 |
| p-value | 0.407 | 0.990 | 0.l02 | |
| Four-meter walking velocity at fastest pace | ||||
| Pearson correlation coefficient with mitochondrial DNA copy number | −0.244 | 0.l78 | 0.624 | 0.l00 |
| p-value | 0.444 | 0.439 | 0.072 | |
| Maximal treadmill walking time | ||||
| Pearson correlation coefficient with mitochondrial DNA copy number | −0.340 | −0.l75 | No data | NA |
| p-value | 0.280 | 0.46l | NA | |
| Pain-free treadmill walking time | ||||
| Pearson correlation coefficient with mitochondrial DNA copy number | −0.044 | 0.390 | No data | NA |
| p-value | 0.892 | 0.099 | NA | |
ABI, ankle–brachial index; MtDNA, mitochondrial DNA; NA, not applicable; PAD, peripheral artery disease.
a
One participant without PAD did not have data for the functional performance measurements.